Product Overview: FINOBRATE-160

FINOBRATE-160 is an effective lipid-regulating tablet manufactured by Knoll. Containing 160mg of active Fenofibrate, it belongs to the fibric acid derivative drug class. It is prescribed alongside diet modifications to lower elevated serum triglycerides and LDL cholesterol, while raising HDL (good) cholesterol, helping to prevent pancreatitis and cardiovascular disease.

Primary Clinical Uses

• Treatment of severe hypertriglyceridemia (high triglyceride levels) with or without low HDL-C.
• Management of mixed dyslipidemia in patients at high risk of coronary heart disease.
• Reduction of cardiac risk in diabetic patients with combined lipid abnormalities.

Therapeutic Benefits

• Triglyceride Reduction: Offers strong, targeted reduction in circulating triglycerides.
• HDL Optimization: Successfully raises cardioprotective HDL (good cholesterol) levels.
• Pancreatitis Prevention: Lowering severe triglycerides significantly reduces the risk of acute pancreatitis.

Possible Side Effects

Common side effects may include:

• Abdominal pain, back pain, or digestive discomfort.
• Headache, dizziness, or mild muscle cramps.
• Reversible elevation in liver transaminases or serum creatinine levels.

How to Take FINOBRATE-160

• Take one tablet daily. The 160mg formulation should be taken with a meal to maximize absorption.
• Swallow the tablet whole with a glass of water. Do not crush, chew, or split.
• Adhere to a low-fat diet throughout the course of therapy.

Mechanism of Action

FINOBRATE-160 contains Fenofibrate, which activates the peroxisome proliferator-activated receptor alpha (PPAR-alpha). This activation enhances the transcription of genes encoding for lipoprotein lipase, apolipoprotein A-I, and apolipoprotein A-II, leading to increased lipolysis and elimination of triglyceride-rich particles from plasma, and boosting HDL synthesis.

Safety Warnings

• Liver & Kidney Health: Contraindicated in patients with severe renal impairment, active liver disease, or gallbladder disease.
• Pregnancy & Nursing: Not recommended during pregnancy or breastfeeding due to safety risks.
• Muscle Pain: Seek medical attention if you experience unexplained muscle pain or weakness, especially when combined with a statin.

Patient Advice

• Maintain regular blood tests to check liver, kidney, and lipid parameters.
• Report any dark urine or yellowing of the skin or eyes immediately.
• Ensure you drink plenty of water to support kidney function.

Fact Box

Drug Interactions

• Statins (Atorvastatin, Rosuvastatin): Co-administration increases the risk of muscle toxicity.
• Oral Anticoagulants (Warfarin): May enhance the anticoagulant effect, increasing bleeding risks.
• Cyclosporine: May increase renal toxicity risks.

User Feedback

• Patients report highly satisfactory triglyceride drops, often bringing values into normal ranges within a month.
• Well-tolerated without significant digestive side effects for the vast majority of long-term users.